CovidV1, Main, Exploration, bibRecord, 001309

Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein

Identifieur interne : 001309 ( Main/Exploration ); précédent : 001308; suivant : 001310

Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein

Auteurs : Heinz Feldmann [Allemagne] ; Stuart T. Nichol [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; Clarence J. Peters [Allemagne] ; Anthony Sanchez [Allemagne]

Source :

Virology [ 0042-6822 ] ; 1994.

RBID : ISTEX:72428862B7F22AA253CE3EAAE64044AC79CD1372

Abstract

Abstract: Eight different filovirus isolates, representing major episodes of filovirus hemorrhagic disease, were propagated for structural and antigenetic analyses of their glycoprotein (GP). Carbohydrate analysis revealed that N- and O-glycosylation are features of filovirus GPs. Oligosaccharide side chains differed in their sialylation pattern and seemed to be cell line-dependent. Marburg virus (MBG) isolates are clearly distinguished from Ebola (EBO) and Reston viruses by a lack of terminal sialic acids when propagated in E6 and MA-104 cells. It was also determined that GP-specific antisera failed to show any cross-reactivity between MBG isolates and other filoviruses. These data, together with prior findings, indicate that the genus Filovirus can be divided into a MBG group and EBO group.

Url:

https://api.istex.fr/ark:/67375/6H6-DCH9W6GZ-C/fulltext.pdf

DOI: 10.1006/viro.1994.1147

Affiliations:

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Le document en format XML

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Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein

Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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